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Temperature mapping and correction of relaxivity changes induced by cooling of the tissue samples (fresh or in situ) are a prerequisite for quantitative MRI in postmortem tissue. In our current research, we assess the temperature-dependency of various relaxation parameters and develop correction schemes for different brain regions.

 
 

Figure 1: (a) Embedded and vacuumed brain slice. (b) Sealed sphere which enables controlled heating or cooling of the mounted brain slice by flushing with tempered water. (c) The refrigerated water bath with a heating immersion circulator.

 

References

** Birkl, C., Langkammer, C., Haybaeck, J., Ernst, C., Stollberger, R., Fazekas, F. and Ropele, S. (2013)
Temperature-induced changes of magnetic resonance relaxation times in the human brain: A postmortem study.
Magn Reson Med. doi: 10.1002/mrm.24799

** Birkl, C; Langkammer, C; Haybaeck, J; Ernst, C; Stollberger, R; Fazekas, F; Ropele, S;
Temperature induced changes of MRI T1 and T2 relaxation times in the unfixed brain.
21st Annual Meeting & Exhibition of the ISMRM; APR 20-26, 2013; Salt Lake City, USA.

** Birkl, C; Langkammer, C; Haybaeck J; Ernst, C; Stollberger, R; Fazekas, F; Ropele, S
Temperature induced changes of MRI relaxation rates in the brain: An unfixed postmortem study.
29th Annual Meeting ESMRMB; Oct 4-6, 2012; Lisbon, Portugal. [Oral Communication]