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Traumatic brain injury (TBI) is a major cause of death and disability, especially in children and young adults. Causes include falls, vehicle accidents, blunt trauma and violence. From a forensic point of view it is especially important to determine reliably whether the cause was an accident or abuse (e.g. shaken baby syndrome) as this information is a basis of jurisdiction in court.
The ultimate goal of this study is to improve the understanding of the extend of brain tissue injury when assessed by MRI. Those insights from postmortem analyses are translated to in-vivo condition and provide a basis for the forensic reconstruction of incidents.

Figure: This study includes 20 subjects deceased of a traumatic brain injury (A) and 20 subjects deceased of non-traumatic reasons. Quantitative MRI takes place directly after death (B) . Following autopsy, several histologic (F,G) and chemical analyses (C,D) are carried out which provide in conjunction with the MRI an inproved understanding how fiber ruptures affect the MRI contrast (E, diffusion tensor imaging).

 

Partner

This TBI study is a cooperative projects with the:

 Homepage: www.cfi.lbg.ac.at

 

References

** Krebs, N; Langkammer, C; Ropele, S; Fazekas, F; Yen, K; Scheurer, E
Post-mortem quantification of traumatic tissue changes in white matter regions using diffusion weighted MRI
BRAIN INJURY. 2012; 26(4-5): 645-645.

** Langkammer, C; Krebs, N; Goessler, W; Yen, K; Fazekas, F; Ropele, S; Scheurer, E
Increased brain iron levels in fatal traumatic brain injury
BRAIN INJURY. 2012; 26(4-5): 620-621.

** Krebs, N; Langkammer, C; Ropele, S; Fazekas, F; Gössler, W; Yen, K; Scheurer, E
Posttraumatic white matter diffusivity changes in postmortem brain.
Proceedings of the ISMRM 20th Annual Meeting. 2012; -ISMRM 20th Annual Meeting & Exhibition; MAY 5-11, 2012; Melbourne, AUSTRALIA.

** Krebs, N; Soellinger, M; Scarpatetti, M; Langkammer, C; Gloor, M; Ropele, S; Fazekas, F; Yen, K; Scheurer, E
Detecting histological changes in traumatic brain injury with magnetization transfer imaging.
Proc Intl Soc Mag Reson Med 19th Annual Meeting #3704# 2011; -19th ISMRM Annual Meeting; MAY 6-13, 2011; Montréal, Canada.

** Krebs, N; Soellinger, M; Scarpatetti, M; Langkammer, C; Gloor, M; Scheffler, K; Ropele, S; Fazekas, F; Yen, K; Scheurer, E
Alterations of Magnetization Transfer Ratio in Traumatic Brain Injury.
Rechtsmedizin. 2011; 21(4):341-432.-8th International Symposium Advances in Legal Medicine (ISALM); SEPT 26-30, 2011; Frankfurt, GERMANY.